We previously established nonmetastic TNBC cell lines (E-Wnt and M-Wnt), derived from spontaneous tumors from the MMTV-Wnt1 transgenic mouse that, when orthotopically transplanted into syngeneic C57BL/6 mice, induce minimally invasive, nonmetastatic, epithelial-like mammary tumors or highly invasive mesenchymal tumors, respectively.16 Obesity enhances transplanted M-Wnt, but not E-Wnt, tumor growth. Here, WNT1 is linked to breast cancer.