MFGE8 and Splenomegaly: Lactadherin, also called milk fat globule epidermal growth factor 8 (MFG‐E8), is a 409 amino acid glycoprotein which has been increasingly investigated and found to play multiple roles in diverse cellular interactions important in both normal biology and states of disease, for example, macrophage phagocytosis, inflammation, adult onset‐autoimmune lupus‐like pathology, splenomegaly, and defective germinal center formation (for review see (Raymond, Ensslin, & Shur, 2009; Aziz, Jacob, Matsuda, & Wang, 2011)).