Compared to the corresponding protein level measured in uninfected cellular extracts, the infection performed with P. gingivalis at a MOI of 100 significantly reduced the expression level of SOCS-3 (5-fold), IRF-1 (5-fold), and EGFR (6-fold), but not STAT-3, in the nuclear extracts (Figure 2a). This evidence concerns the gene STAT3 and infection.