The levels of the phosphorylated and total forms of PI3K and AKT were also reduced after both 30 min and 3 h of infection with Kgp- and Rgp-deficient mutants (KDP129 and KDP133, respectively), but not after infection with the gingipain-null mutant (KDP136; Fig. 4(B) and (C)). This evidence concerns the gene AKT1 and infection.