CD8A and cutaneous leishmaniasis: In spite of that difference, the F1 domain, which induced a CD8+ T-cell-mediated protection against cutaneous leishmaniasis of mice (22, 24, 25), shares important epitopes for the generation of a Th1 and CD8+ T-cell responses of human VL patients infected with L. (L.)infantum chagasi from Sergipe, Brazil (28).