The lack of association of OPN, a molecule deeply involved in the development of obesity-associated insulin resistance as evidenced by previous works23, 29, 31 and the correlations observed in the present study, with the adiponectin/leptin ratio suggest the potential involvement of other factors secreted by the adipose tissue in inflammation and oxidative stress37, 38. This evidence concerns the gene LEP and obesity due to melanocortin 4 receptor deficiency.