Discordantly classified participants differed most markedly in estimated glomerular filtration rate (eGFR) and the prevalence of type 2 diabetes mellitus (T2DM): prevalence of eGFR <60 mL/min/1.73 m2 was 7.6% in participants with isolated high hs-cTnT levels compared with 1.5% for participants with isolated high hs-cTnI levels (see Supplementary Table S7). This evidence concerns the gene TNNI3 and diabetes mellitus.