Breast cancer tumor samples have been subdivided into five molecular subtypes according to St Gallen International Expert Consensus 2013: luminal A (ER and PGR-positive, human Ki-67 protein <14%, histological grade 1 or 2 and HER2-negative), luminal B1, HER2-negative (ER-positive, PGR <10% or negative, Ki-67 > 14% and high grade), luminal B2 HER2-positive (ER-positive and PGR-negative), HER2-positive non-luminal (ER and PGR-negative) and TNBC (ER, PGR and HER2-negative). The gene discussed is ERBB2; the disease is breast cancer.