HES1 and Hepatic fibrosis: To investigate whether lnc-LFAR1 also affects other liver fibrosis-related pathways with the exception of TGFβ pathway, we detected these pathways components or target genes, including Wnt target genes Cyclin D1 and Myc21, Hippo target genes Ankrd1 and Areg22, Notch signaling-related molecules and target genes Notch2, Notch3, Hes1 and Hey2 and Hedgehog target genes Ptch1 and Gli123,24, in lnc-LFAR1 downregulated HSCs.