SMAD2 and Hepatic fibrosis: Moreover, we validate lnc-LFAR1 interacts with the transcriptional factor Smad2/3 by RIP assay and our data suggest that knockdown of lnc-LFAR1 dramatically inactivates fibrotic TGFβ/Smad and Notch pathways in both HSCs and HCs and thereby inhibiting CCl4- and bile duct ligation (BDL)-induced mouse liver fibrosis in vivo.