CHEK2 and cancer: Indeed, Akt can modulate the function of several molecules as PP2C-alpha, YWHAZ, MAPK8, PAX2, PAK1, CASP-9, CASP-7, DFF-45, NPM, PAX2, CDK1, CDK2, CHEK2, involved in apoptosis inhibiton, cell cycle promotion and cancer progression.