Interestingly, in two independent data sets38–40, AIM1 mRNA expression was greatly reduced in metastatic prostate cancer compared to primary cancer or benign prostate (Fig. 8c), consistent with the observation of reduced AIM1 protein expression in metastatic cancers and with a role of AIM1 loss in migration and metastatic dissemination. The gene discussed is CRYBG1; the disease is metastatic malignant neoplasm.