CRYBG1 and cancer: Overall, the observations of AIM1 dysregulation through mislocalization, reduced expression, and genomic loss suggests that initial mislocalization and dissociation of AIM1 away from the actin cytoskeleton can promote formation of invasive carcinoma and high-grade cancers, and that further loss of AIM1, through decreased gene expression and/or genomic deletion, can be associated with development of recurrence and formation of metastases.