CRYBG1 and Familial prostate cancer: Although we could identify an AIM1 TSS-proximal CpG island at which methylation was inversely correlated with mRNA expression in prostate cancer cell lines (Supplementary Fig. 6C, D), hypermethylation at this region was not observed in primary tumors (0/20) or metastases (0/24) (Supplementary Fig. 6E).