Interestingly, RWPE-1 cells depleted of AIM1 were characterized by complete absence of branching ductal structures and disrupted and disorganized acinar structures with stellate protrusions (Fig. 5i), similar to spindle-like filopodia seen in comparable 3D culture conditions of other invasive prostate cancer cell lines33. Here, CRYBG1 is linked to prostate carcinoma.