Importantly, in prostatic adenocarcinoma, the high degree of co-localization between AIM1 and β-actin seen in normal prostate tissues was profoundly disrupted (mean co-localization coefficient = 0.38, SD = 0.08), with AIM1 showing a diffuse cytoplasmic distribution and no accentuated membranous staining, and with β-actin showing a disrupted, patchy, membranous, and cytoplasmic localization pattern (Fig. 7a, b). The gene discussed is ACTB; the disease is prostate adenocarcinoma.