RAP2A and neoplasm: However, we did not find significant correlation between Rap2a expression with clinicopathologic variables, including TNM stages (P = 0.800), depth of invasion-pT status (P = 0.854), lymph node metastasis-pN status (P = 0.319) (Fig. 1C–E), age (P = 0.518), gender (P = 0.375) and tumor size (P = 0.516) (Table 1).