We then tested infection by the transmitted founder (T/F) viruses RHPA, SUMA, WITO, THRO, and ZM247 (Fig. 4B and C): SUMA, WITO, and THRO infectivities were all reduced by ∼6- to ∼10-fold by SUN1, whereas RHPA and ZM247 were largely unaffected (Fig. 4B and C). The gene discussed is SUN1; the disease is infection.