FOXP3 and type 1 diabetes mellitus: Furthermore, we noted that the increased frequency of FOXP3+ cells was mainly restricted to the CD127lowCD25low T cell subset, as we observed only a small increased frequency of conventional CD127lowCD25highFOXP3+ Tregs in T1D patients (5.6%) compared to healthy donors (4.8%; P = 8.0 × 10−3; Supplementary Fig. 2).