Adipocytokines such as leptin, adiponectin, resistin, interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) are mediators produced by adipocytes which have important roles in the pathophysiology of insulin resistance, inflammation, hypertension, endothelial dysfunction and atherosclerosis [12–18]. This evidence concerns the gene LEP and endothelial dysfunction.