In an elegant study, Hodgin et al. used laser micro-dissection to analyze gene expression changes in glomeruli from three pre-clinical mouse models: a type I diabetes model (STZ-induced diabetes in DBA2 /J mice), an obese model of type 2 diabetes (db/db leptin receptor mutation on C57BLKS background; BKS db/db), and an obese and hypertensive model of type 2 diabetes (BKS db/db eNOS-/- mice). The gene discussed is LEPR; the disease is type 1 diabetes mellitus.