In contrast, and consistent with the progressive nature of nephropathy in ZSF1 rats, our longitudinal analysis revealed a strong concordance between week 34 onwards obese ZSF1 rats and the gene expression changes in human DN glomeruli reported by Hodgin et al. We note that putative tubule-specific genes, such as Kim-1 and Slc34a2, emerge from our analyses (Fig 6). This evidence concerns the gene HAVCR1 and kidney disorder.