LGI1 and paraneoplastic neurologic syndrome: In paraneoplastic neurological syndromes (PNNS) antibodies are directed against targets such as amphisphysin, Hu ̧ Ri, Yo, Tr, collapsing response-mediator protein (CRMP5/POP66), voltage-gated calcium channels (VGCC), nicotinic acetylcholine receptors (AChR), Purkinje cell cytoplasmic antibody (PCA2), n-methyl-D-aspartate receptor (NMDAR), and leucine-rich glioma-inactivation protein 1 (LGI-1) [11–14].