One experimental study found that ofloxacin drops accelerate the closure rate to a greater extent than either saline or dexamethasone.[22] In another study, ofloxacin drops, oral amoxicillin, or ofloxacin drops plus oral amoxicillin were used to treat traumatic TMPs in patients with secondary infections; only ofloxacin drops-alone accelerated the closure time.[23] The objective of our study was to compare the healing outcomes afforded by EGF, FGF-2, and 0.3% (w/v) ofloxacin drops on large human traumatic TMPs; control groups underwent only conservative observation. This evidence concerns the gene EGF and infection.