In the discussion, the most important thing should be discussed is the Vaspin, which is one of the adipokines and associated with obesity,[26] and LVBG is one of the most frequent and effective treatments for morbid obesity.[27] We investigated the role of serum vaspin level in predicting the amelioration of fatty liver and metabolic disturbance in patients with severe obesity following LVBG. The gene discussed is SERPINA12; the disease is obesity disorder.