SERPINA12 and polycystic ovary syndrome: Laparoscopic restrictive bariatric surgery reduced the serum vaspin levels by decreasing dietary intake in a short term.[38] However, elevated serum vaspin level was observed in women with polycystic ovary syndrome in response to weight loss, because a small weight reduction cannot affect serum vaspin levels significantly.[39] Thus, it's proved that the serum vaspin level can be reduced by the patients having large weight reduction.