SERPINA12 and Insulin resistance: Besides, serum vaspin level is closely associated with insulin resistance because fatty liver increased while serum vaspin level decreased.[32] Weight loss affects serum vaspin level in obese people by the regulation of insulin resistance.[33] The findings in this study support our assumption, that there seems to be a strong association between low-expressed vaspin and also fatty liver through the mechanism of insulin resistance, this is the most important thing.