In the deep cases, it is also proved that there is a positive association between serum vaspin levels and metabolic disturbance in the humans.[19] Dysregulation of adipokines production with anti-inflammatory properties may contribute to metabolic disturbance related to obesity.[28] The vaspin demonstrated by the Phalitakul et al[29] is considered as a novel adipokine, which plays an anti-inflammatory role in vascular smooth muscle cells. Here, SERPINA12 is linked to obesity due to melanocortin 4 receptor deficiency.