SERPINA12 and Insulin resistance: And it completely proved that through the signaling pathways, the substrate flux are leading the pathogenesis of insulin resistance.[34] And adipokines regulate various insulin resistance-related pathways through 3 mechanisms: endocrine, paracrine, or autocrine.[35] Thus, it is reasonable to hypothesize that vaspin plays a role in modulating insulin resistance-related signaling pathways of via secretion.