BRCA2 and breast cancer: Among the 5–10% of genetically based BC cases, many were caused by inherited mutations in either the BRCA1 or the BRCA2 genes (Anderson and Badzioch, 1993; Blackwood and Weber, 1998), which, according to the number of cohorts, showed a marked increase in penetration over the recent decades, possibly reflecting increased western reproductive and lifestyle risk factors, including western diet, over-fatness, smoking, and low physical activity (Friebel et al., 2014; Pettapiece-Phillips et al., 2015).