In contrast, aspirin, the inhibitor of cyclooxygenase 2 – the enzyme that converts long-chain PUFAs into their eicosanoids – was associated in a western high n-6 diet with reduced n-6 procarcinogenic/proinflammatory compounds (Fig. 2), resulting in improved BC survival and reduced BC and all-cause mortality, as well as with reduced relapse/metastasis when taken before diagnosis (Huang et al., 2015) (although taking after diagnosis was not significantly effective) (Barron et al., 2015). The gene discussed is PTGS2; the disease is breast cancer.