Postmenopausal overweight is associated with increased peripheral conversion of androgens to estrogens, decreased sex hormone-binding globulin, and increased insulin levels, especially among obese smokers and drinkers (Endogenous Hormones Breast Cancer Collaborative Group et al., 2011), and alcohol intake further increases the synthesis of androgens and estrogens (Rinaldi et al., 2006). Here, INS is linked to breast cancer.