Influenza‐associated IHD is posited to be driven by inflammation which is known to have a critical role in the development of acute coronary syndrome.65 In apolipoprotein E‐deficient mice, an animal model of atherosclerosis, animals that were infected with influenza A virus developed subendothelial and smooth muscle inflammatory infiltration with overlying platelets and fibrin strands in atherosclerotic plaques.66 Additionally, the systemic pro‐inflammatory response triggered by influenza infection is accompanied by significant pro‐coagulant effects which may also play a role.67 This evidence concerns the gene APOE and acute coronary syndrome.