The FIB-4, an index based on simple laboratory parameters, e.g. age, aspartate aminotransferase (AST), platelet count (PLT), alanine aminotransferase (ALT) has been developed to rule out (FIB-4 <1.45: negative predictive value, NPV: 90%) or include (FIB-4 >3.25: positive predictive value, PPV: 65%) advanced fibrosis (ADVFIB, i. e. This evidence concerns the gene GPT and fibrosis.