A comparison of the transcriptional responses of epithelial cells to infection with a tepP-deficient mutant and TepP-overexpressing strains indicated a role for TepP in the induction of a subset of genes associated with type I interferon (IFN) responses, including interferon-induced peptides with tetratricopeptide repeats (IFIT [20]) (6). The gene discussed is SPMIP8; the disease is infection.