LCN2 and acute kidney injury: In a prospective, double-blind, placebo-controlled, randomized trial of 26 hyperuricemic patients undergoing cardiac surgery, there was no observed benefit on postoperative serum creatinine (SCr) in rasburicase versus placebo treatment groups, although novel AKI biomarkers such as urinary NGAL (uNGAL) tended to be lower in rasburicase-treated patients [42].