SOD1 and cancer: However, SOD levels also increase with tumor progression in these and other cancers (Ray et al., 2000; Chung-man Ho et al., 2001; Dhar et al., 2011; Miar et al., 2015), with similar changes occurring in other antioxidants, such as cytoplasmic SOD1 and catalase (Miar et al., 2015).