Comparisons between hepatocellular carcinoma and healthy liver samples using these models indicate that tumors display an increased abundance of NADPH-producing enzymes (e.g., ME1, G6PD, TALDO1, and TKT) and that H2O2 may be used as reporter metabolite in some of the patients (Bjornson et al., 2015). The gene discussed is TALDO1; the disease is hepatocellular carcinoma.