Considering that G6PD catalyzes the first and rate-limiting step of PPP and that it has a role in controlling the intracellular redox environment, this enzyme has been envisaged as one of the potentially most important therapeutic cancer redox targets (Wang et al., 2012; Patra and Hay, 2014; Zhang et al., 2014; Nóbrega-pereira et al., 2016), and it has been included in pre-clinical trials (Budihardjo et al., 1998; De Preter et al., 2015). The gene discussed is G6PD; the disease is cancer.