This segregation signature was developed by us using prototype, proneural, and mesenchymal subtype-specific glioblastoma long-term cell cultures and comprises four genes: angiopoietin1 (ANG1), angiopoietin-2 (ANG2) and vascular endothelial growth factor A (VEGF-A) and vascular endothelial growth factor B (VEGF-B). This evidence concerns the gene ANGPT2 and glioblastoma.