VEGFB and glioblastoma: Furthermore, analysis of two large glioblastoma data sets (5, 6) substantiated our findings and revealed prominent overexpression of ANG and VEGF isoforms in mesenchymal glioblastomas (Verhaak data set: ANG1, ****p < 0.0001; ANG2, *p < 0.03; VEGF-A, *p < 0.03; VEGF-B, ***p < 0.0003, and TCGA data set: ANG1, ****p < 0.0001; ANGPT2, **p < 0.0027; VEGF-A, **p < 0.0085; VEGF-B, *p < 0.0429) (Figure 3D).