The frequency/number of Gr1+CD115+CCR2highCX3CR1lowmonocytes in primary tumor and peripheral blood (Supplementary Fig 3) and in vivo S100A9-SPECT signal in lungs (Figure 5a, top panels and Fig 5b) correlated with the respective metastatic potential of the underlying model: inflammatory monocytes and S100A9 were significantly increased in the 4T1.2 model as compared 67NR or control mice. This evidence concerns the gene S100A9 and neoplasm.