Dysregulation of the hypothalamic-pituitary-adrenal axis is frequently associated with depression [40], intervention with the glucocorticoid receptor (GR) system successfully reversed the depressant phenotype in mice [41], and we found that herb Cistanche significantly alleviated the serum concentration of CORT (Figure 6(b)). This evidence concerns the gene NR3C1 and depressive symptom measurement.