After adjusting for age, sex, BMI, duration of diabetes, FPG, HbA1C, eGFR, current smoking, current drinking, hypertension, and use of ACEI/ARB, ORs for elevated SCC, Cyfra21-1, and CEA levels were slightly attenuated but remained significant (Table 4, model 2). The gene discussed is CEACAM5; the disease is diabetes mellitus.