For example, repeated long bouts (e.g., two bouts of 90 min) of moderate-intensity exercise performed on the same day have been shown to lead to reductions in glucagon and other counter-regulatory hormones, as well as reductions in sympathetic nerve activity, which persist until at least the next day in people with type 1 diabetes (T1D) (8) and in healthy participants (9). The gene discussed is GCG; the disease is type 1 diabetes mellitus.