ADIPOQ and fatty liver disease: On the other hand, circulating levels of adiponectin are negatively correlated with obesity and the presence of diabetes (Hotta et al., 2000), and have been shown to improve insulin sensitivity and glycemic control (Yamauchi and Kadowaki, 2013), increase expansion of adipose tissue under chronic high-fat diet feeding (Asterholm and Scherer, 2010), and prevent the development of fatty liver disease (Awazawa et al., 2009; Asterholm and Scherer, 2010).