The major findings in this study are that (1) RosA is calculated as a potential therapeutic molecule to attenuate/cure cardiovascular diseases using text mining, chemometric and chemogenomic methods, (2) RosA attenuates I/R-induced myocardial injury through inhibiting inflammation and cardiomyocyte apoptosis, (3) RosA inhibits inflammation and cell apoptosis through activating PPARγ and down-regulating NF-κB-mediated signaling pathway. This evidence concerns the gene PPARG and cardiovascular disorder.