DISC1 and schizophrenia: In addition, maternal immune activation, by poly(I:C), was shown to specifically interact with a discrete point mutation of DISC1 and exacerbated schizophrenia-related behaviors in mice, giving further support to the hypothesis that inflammation during development is an important factor in the pathophysiology of schizophrenia and linked to genetic traits (Abazyan et al., 2010; Lipina et al., 2013).