However, hereditary factors are likely to play an important role as polymorphisms of the Disrupted in schizophrenia 1 (DISC1) gene is an important genetic abnormality in schizophrenia, resulting in disruption of scaffolding proteins in spines and substantial changes of structural synaptic plasticity (Lipska et al., 2006). The gene discussed is DISC1; the disease is schizophrenia.