Further support comes from the observations that a lack of galectin-3 facilitates motor function recovery after spinal cord injury (Mostacada et al., 2015), and that galectin-3 contributes to hypoxic-ischemia injury and ischemia-induced neuronal death (Doverhag et al., 2010; Satoh et al., 2011), findings that suggest a role for galectin-3 in negative regulation of neuronal plasticity. This evidence concerns the gene LGALS3 and ischemia.