Thus, while some groups have reported neither effects of BDNF and NT-3 on motoneuron survival when exposed to glutamate toxicity in culture (Corse et al., 1999), nor an increase in lifespan in ALS mouse models (Park et al., 2009), other groups have demonstrated an improved motor function and an increased survival of motoneurons treated with BDNF or NT-3 in different murine models of ALS (Mitsumoto et al., 1994; Ikeda et al., 1995; Haase et al., 1997; Kaal et al., 1997). Here, NTF3 is linked to amyotrophic lateral sclerosis.