Similarly, a Thy-1+ CD45− Epcam− population of CAFs has been isolated from KrasLA1 mice, which develop multifocal lung adenocarcinomas owing to somatic activation of a latent KrasG12D allele14; these CAFs exhibit biochemical and morphological properties of myofibroblasts, secrete diverse growth factors and pro-angiogenic and immunosuppressive cytokines15, and promote the invasive properties of lung adenocarcinoma cells derived from KrasLA1 mice in co-culture studies15. This evidence concerns the gene PTPRC and lung adenocarcinoma.