This is in agreement with recent observations of Chen and collaborators who show that EZH2 inhibition, by EPZ005687, delays OA development in experimental osteoarthritis model in mice, and reduced the expression of the enzymes of extracellular matrix breakdown such as MMP-3, MMP-13 and ADAMTS-5 in OA cartilage13. Here, MMP3 is linked to osteoarthritis.