Several candidate genes related to transcription factors that may be important for the stemness of cancer stem cells (Rcor2, Klf2, Klf4, Klf6 and Hif-1α) and LIC differentiation (Cebpa, Gata2 and Pu.1), but not for self-renewal, were notably changed in B7-H4-null LICs (Supplementary Figures 4a and b). The gene discussed is VTCN1; the disease is cancer.