To rule out the connections between B7-H4 and RCOR2, we examined several signaling pathways that might be regulated through B7-H4 and eventually observed that serine/threonine kinase 1 (AKT) signaling was notably strengthened in B7-H4-null AML cells (Figure 2b, first panel). The gene discussed is VTCN1; the disease is acute myeloid leukemia.