TP53 and central nervous system cancer: In the present study, PARP cleavage, activation of caspase-3, -7, -8, and -9, mitochondrial morphological changes and loss of mitochondrial membrane potential, imbalance of Bcl-2 family expression, overproduction of ROS and superoxide anion, DNA damage and p53 phosphorylation (Ser15), dys-regulation of MAPKs and PI3K/AKT pathways were all detected after SeC treatment in human glioma cells, which suggested the consistency of Se-containing compounds-induced apoptosis.