Combining the data from our present study with the data from previous study, indicating the increase of serum adiponectin along with a decline in the estimated glomerular filtration rate in pre-dialysis CKD patients, it seems likely that the increase of serum adiponectin in pre-dialysis CKD patients might be involved in the development of AAC, leading to increased mortality. The gene discussed is ADIPOQ; the disease is chronic kidney disease.