FBXW7 and hypertrophy: Echocardiography showed that LVEF and LVFS were decreased in Aggf1+/− mice compared with WT mice; TAC reduced LVEF and LVFS in WT mice; Combination of TAC and Aggf1 haploinsufficiency further aggravated hypertrophy and heart failure by reducing LVEF and LVFS more; Ago-miR-183-5p rescued the reduction of LVEF and LVFS induced by TAC in WT mice; Ago-miR-183-5p rescued the reduction of LVEF and LVFS induced by TAC and Aggf1 haploinsufficiency (Fig. 7b–g).