In order to confirm our finding that AGGF1 protein therapy can successfully inhibit cardiac hypertrophy and heart failure and improve cardiac function, we injected adeno-associated viruses AAV9-AGGF1 into the myocardium of mice to drive the ectopic expression of AGGF1 in myocardial cells (AAV9-GFP viruses as control). This evidence concerns the gene AGGF1 and heart failure.