From this data, we identified two stable endogenous reference miRNAs that are suitable for the normalisation of plasma miRNA expression in addition to synthetic spike in miRNAs, such as cel-miR-39 and ath-miR159a, which will allow for more accurate qPCR normalisation for studying oestrogen responsive miRNAs that may be involved in regulating other haemostatic factors leading to Protein S deficiency during pregnancy. Here, PROS1 is linked to hyperinsulinemic hypoglycemia, familial, 4.