A group in Belgium that has already completed a phase I/II study on vaccination with WT1 mRNA-loaded DCs for 10 AML patients in remission with high risk of relapse demonstrating immunological as well as clinical responses [102] is now conducting a phase II study testing the induction of immune and molecular responses by vaccination with WT1 mRNA-loaded DCs for AML as well as chronic myeloid leukemia and multiple myeloma patients (NCT 00965224). The gene discussed is WT1; the disease is plasma cell myeloma.