Similarly, in glioblastoma, Liu et al demonstrated that miRNA-101 inhibits proliferation, migration and invasion of glioblastoma by targeting SOX9 [40], Michiel et al also found that miRNA-101 is down-regulated in glioblastoma resulting in EZH2-induced proliferation, migration, and angiogenesis [41]. This evidence concerns the gene SOX9 and glioblastoma.