ITPR2 and type 2 diabetes mellitus: The mean level of IP3R2 staining in beta cells from 12 donors with type 2 diabetes was significantly higher than in the 9 controls (mean ± SEM: 54.27±2.11 pixels from 261 islets from donors with type 2 diabetes vs 33.03±1.28 pixels from 178 control islets) using Mann-Whitney test (two tailed p value < 0.0001) as shown in Fig 2B.