Chromosome 7 is known to harbor genes whose alteration my play an important role in multiple diseases as cystic fibrosis[27], but also in tumorigenesis [28]with over than 1150 protein- coding genes, 605 of which have been validated by transcript sequences.[29] Nevertheless, three genes; EGFR, MET, and BRAF emerge as of special interest in NSCLC. The gene discussed is BRAF; the disease is cystic fibrosis.