IGF1R and non-small cell lung carcinoma: While IGF1R SISH analyses seems to give additional information about the subgroup of NSCLC patients, who most likely would benefit of an anti-IGF1R therapy regimen, the MET SISH analyses seem to be biased when investigating the ratio of gene copy number to chromosome count due to the highly negative prognostic significance of chromosome 7 polysomy, higher than 3 chromosome copies.