While, in the adenocarcinoma patient population, independent of other clinicopathological variables, a high cytoplasmic MET expression was a significant negative prognosticator, as determined by IHC, a similar correlation was not found in patients with MET gene copy number gain, i.e. the absolute MET gene copy number in tumor cells did not affect the prognosis. The gene discussed is MET; the disease is adenocarcinoma.