This process is described as the detoxifying role of MTs against Cd toxicity [37] The effect of Cd addition on physiological Zn transport and homeostasis, as well as the regulatory effect of Zn on Cd-induced cytotoxicity was evaluated in this study, as a follow-up to our previous study using RA synoviocytes pre-exposed or not to IL-17/TNF induced-inflammation. The gene discussed is TNF; the disease is rheumatoid arthritis.