Zinc alone slightly reduced IL-6 production in comparison to control in RA synoviocytes cultured with PHA-activated PBMCs (mean ± SD 409 ± 114 ng/ml in the RA control versus mean ± SD 152 ± 99 ng/ml in Zn treated PHA activated RA co-cultures, p<0.05). Here, IL6 is linked to rheumatoid arthritis.