CFH expression occurs in normal renal cortical tubules[37] and recently, THP and CFH have been identified colocalizing in the renal tubules in IgA nephropathy patients.[36] While normal urinary CFH concentrations are low (0–14 U ml-1), increased CFH concentrations (ranging from 15 U ml-1 to 52,198 U ml-1) were detected in patients with a wide range of renal diseases.[38]. This evidence concerns the gene CFH and IgA glomerulonephritis.