Additionally, future studies may be warranted that address how a complement regulatory function of THP may relate to the pathogenesis of autosomal dominant tubulointerstitial kidney disease, UMOD-related (ADTKD-UMOD), a chronic, progressive disease characterized by tubulointerstitial fibrosis in individuals with mutations in THP/uromodulin.[52]. Here, UMOD is linked to autosomal dominant medullary cystic kidney disease with or without hyperuricemia.