Despite some limitations of these preclinical models, the present results demonstrate that the effects of BTK inhibition with BMS-986142 on antigen-specific BCR-mediated B-cell functions, IgG-containing IC signaling through FcγR in monocytic cells, and RANK-dependent osteoclastogenesis are anticipated to provide clinical benefit in the treatment of autoimmune disorders such as RA. Here, FCGR2A is linked to autoimmune disease.