Insulin deficiency and the lack of a trophic effect of insulin on acinar cells[6]as well as the chronic inflammation associated with insulitis [8, 9]may explain the reduction in pancreas size in type 1 diabetes (T1DM), whereas atherosclerosismight play a role in type 2 diabetes (T2DM) [10, 11]. The gene discussed is INS; the disease is type 1 diabetes mellitus.